Down-regulation of Glial Fibrillary Acidic Protein (GFAP) during the development of a marine fish (Dentex dentex L.)
DOI:
https://doi.org/10.3989/scimar.1998.62n4357Abstract
A band of approximately 52-53 kDa, corresponding to glial fibrillary acidic protein (GFAP) was detected by immunoblot techniques in brain tissue of a marine fish (Dentex dentex L). The aim of this study was to quantify the density of GFAP during the life cycle of a marine fish in the wild. The levels of GFAP immunoreactivity were determined at two different stages of development: juvenile (body weight range: 180-360 g) and sexually developing-mature specimens (body weight range: 2329-5550 g) from a natural population in the Western Mediterranean Sea. Our results indicated a negative correlation between the immunoreactivity of GFAP and weight in the sexually developing-mature group of fishes (r=-0.785, p<0.05, n=8). These findings might be of relevance in understanding the role of GFAP in the development of the central nervous system and demonstrate that GFAP down-regulation in D. dentex brain tissue during development is a natural physiological phenomenon.
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Published
1998-12-30
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1.
Busquest X, Morales-Nin B. Down-regulation of Glial Fibrillary Acidic Protein (GFAP) during the development of a marine fish (Dentex dentex L.). scimar [Internet]. 1998Dec.30 [cited 2023Dec.3];62(4):357-60. Available from: https://scientiamarina.revistas.csic.es/index.php/scientiamarina/article/view/980
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