Oxidative stress biomarkers in the gills of the bivalve <em>Mactra stultorum</em> exposed to acrylamide

Wafa Trabelsi; Chaima Fouzai; Imene Chetoui; Safa Bejaoui; Khaoula Telahigue; Imen Rabeh; Mhamed El Cafsi; Nejla Soudani

doi:10.3989/scimar.04993.11A

Autores/as

Wafa Trabelsi Laboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. Tunis https://orcid.org/0000-0002-1114-4080
Chaima Fouzai Laboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. Tunis https://orcid.org/0000-0001-7588-1859
Imene Chetoui Laboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. Tunis https://orcid.org/0000-0002-2259-5397
Safa Bejaoui Laboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. Tunis https://orcid.org/0000-0002-7946-2763
Khaoula Telahigue Laboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. Tunis https://orcid.org/0000-0001-8841-9911
Imen Rabeh Laboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. Tunis https://orcid.org/0000-0002-0307-473X
Mhamed El Cafsi Laboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. Tunis https://orcid.org/0000-0002-9771-1110
Nejla Soudani Laboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. Tunis https://orcid.org/0000-0002-7652-9678

DOI:

https://doi.org/10.3989/scimar.04993.11A

Palabras clave:

acrilamida, exposición, Mactra stultorum, branquias, estado antioxidante, acetilcolinesterasa

Resumen

La acrilamida (ACR) es uno de los contaminantes más perjudiciales en el medio ambiente y presenta un grave riesgo para los seres humanos y los ecosistemas. El objetivo de este estudio es evaluar los efectos del ACR administrado a diferentes concentraciones (5, 10 y 20 mg L^–1) con el fin de evaluar el estado antioxidante en las branquias de Mactra stultorum. Nuestros resultados mostraron, después de 5 días de tratamiento, un aumento en los niveles de malondialdehído (MDA), hidroperóxidos lipídicos (LOOH), proteínas de oxidación avanzada (AOPP), glutatión reducido (GSH), ácido ascórbico (vit C) y metalotioneínas (MTs) en las branquias de las almejas tratadas en comparación con los controles. Además, también se observó un aumento en la superóxidodismutasa (SOD) y una disminución significativa en las actividades de glutatión peroxidasa (GPx). La acrilamida indujo neurotoxicidad como lo demuestra la inhibición de la actividad de la acetilcolinesterasa (AChE) de una manera dependiente de la dosis. En general, nuestros resultados indicaron que el estrés oxidativo puede considerarse como uno de los mecanismos detrás de la toxicidad por ACR en los bivalvos, aunque el tópico debería beneficiarse de más investigaciones.

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